association between betaine homocysteine s-methyl transferase (bhmt) rs3797546 gene polymorphisms and the risk of nonsyndromic cleft lip and/or cleft palate in south-east population of iran

results no significant difference was found between the groups regarding bmht rs3797546 gene polymorphism. the c allele was not associated with ns-cl/p (or = 1.27, 95% ci = 0.85-2.79, p = 0.690). conclusions our data suggested that bmht rs3797546 gene polymorphism was not associated with risk/ protection for ns-cl/p in a sample of iranian population. larger studies are required to validate our findings. materials and methods this case-control study was performed on 100 ns-cl/p cases and 100 healthy controls. tetra amplification refractory mutation system-polymerase chain reaction (t-arms-pcr) was used to detect the polymorphism. analysis of data was done using χ2 test for categorical data, the associations between genotypes and ns-cl/p were estimated by computing the odds ratio (or) and 95% confidence intervals (95% ci) from logistic regression analyses. objectives the present study was aimed to evaluate the possible association between bhmt rs3797546 gene polymorphisms and ns-cl/p in a sample of iranian population. background nonsyndromic cleft lip with or without cleft palate (ns-cl/p) is one of the most common congenital anomalies and has a multifactorial etiology that involves both genetic and environmental factors.